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KMID : 1123920110250030516
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 3 p.516 ~ p.520
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Effect of Water Extract of Saussureae Radix in RANKL-induced Osteoclast Differentiation
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Lee Myeung-Su
Kim Jeong-Joong
Oh Jae-Min
Choi Min-Kyu
Song Mi-Jin
Ahn Yong-Hwan
Lee Jeong-Hugh
Jeon Byung-Hoon
Park Kie-In
Jang Sung-Jo
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Abstract
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Osteoporosis is social problem around the world, because fracture of old age may lead to critical medical condition. Osteoclast is a main target for prevention and treatment of osteoporosis due to their responsibility for bone resorption. Saussureae Radix has been known that has gastro-protective, bronchodilatory effect and has a anti-biotic effect. Saussureae Radix has been widely used in Oriental medicine. However, the effect of extract of Saussureae Radix in osteoclast differentiation remains unknown. Thus, we examined the effect of Saussureae Radix in receptor activator of nuclear factor-χB ligand (RANKL)-induced osteoclast differentiation. From the results of our study, Here we found that Saussureae Radix significantly inhibited osteoclast differentiation induced by RANKL. Saussureae Radix suppressed the activation of NFχB in bone marrow macrophages (BMMs) treated with RANKL. Also, Saussureae Radix significantly inhibited the mRNA expression of c-Fos, tartrate-resistant acid phosphatase (TRAP), osteoclast-associated receptor (OSCAR), nuclear factor of activated T cells (NFAT)c1 and cathepsin K in BMMs treated with RANKL. Particularly, Saussureae Radix greatly inhibited the protein expression of c-fos and NFATc1. especially in the case of NFATc1 expression, a master transcription factor of the differentiation of osteoclasts is very important step for osteoclastogenesis. These results demonstrate that Saussureae Radix may be useful treatment option of bone-related disease such as osteoporosis and rheumatoid arthritis.
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KEYWORD
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Saussureae Radix, osteoporosis, osteoclast, RANKL
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